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Joseph Lister used cultures of their own urine to analyze the microbiology of air. He noted when moulds were seen in his cultures, the bacteria which are there appeared non-motile and degenerate, whereas if bacteria grew without moulds, we were holding highly motile. Lister determined that moulds produced an element or substances that adversely affected the viability of bacteria. He then reasoned that culture filtrates removed from moulds should prevent infection if accustomed to irrigate surgical wounds. In its modern-day use, it refers primarily to cytotoxic drugs used to deal with cancer. Epiglottitis affects more men than women. Hib bacteria spread rapidly when individuals will be in close contact and weak body's defence mechanism. Medicines or diseases that weaken the body's defence mechanism could make adults prone to epiglottitis. Epiglottitis requires urgent endotracheal intubation to guard the airway. 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